I was also told by an ER Dr. to give my 4 yr. old grand daughter Tylenol and Motrin at the same time. I’m not a Dr. or Pharmacist but the idea of doing this scares me. I am giving her only Motrin as my instincts tell me taking both together does not sound safe. Motrin has worked best for her in taking down her fever. Acetaminophen/Ibuprofen Dosage Chart Acetaminophen (Tylenol® or another brand) Give every 6 hours as needed. Do not give more than 4 doses in 24 hours. Weight in pounds (lbs.) Acetaminophen liquid 160mg*/5ml *Double check concentration 5-6.5 lbs. 40 mg (1.25 ml) 6.5-8 lbs. 48 mg (1.5 ml) 8-10.5 lbs. 64 mg (2 ml) 10.5-13 lbs. 80 mg (2.5 ml) 13-16 lbs. 96 mg (3 ml) 16-20.5 lbs. 120 mg (3.75 ml. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Chowdhury on can you give a toddler benadryl and tylenol: Tylenol (acetaminophen) is certainly safe in the toddler age group. I only use Benadryl for hives and allergies. Can patients take Benadryl and Tylenol together for Migraine headache or Cold and Flu Since, there is no significant interaction between diphenhydramine and acetaminophen, patients can take Benadryl and Tylenol together in recommended doses for a short period of time. Tylenol, containing the active ingredient acetaminophen, and ibuprofen, sold under various trade names such as Advil and Motrin, can be used safely in combination to relieve pain and fever for short periods of time. Motrin is a nonsteroidal anti-inflammatory drug , which, like Tylenol, exerts its effects on cyclo-oxygenase and inhibits prostaglandin synthesis. Prostaglandins mediate pain, inflammation, and fever. Several large research studies have shown that ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) together work well to relieve pain with few side effects. In fact, even for extreme dental pain, these medications combined work better than many opioid pain medications (like Vicodin or Norco). Someone said that you should never give Ibuprofen and Tylenol together the same time however this is incorrect. My son had 105.5 degree fever a couple months ago and the ER physician said that alone each can only drop a fever three degrees at the most so both are given if the fever is high enough. Noted pediatrician Dr. William Sears’ advises on his website that it is OK to give acetaminophen (Tylenol) together with ibuprfoen (Motrin or Advil): For very high or stubborn fevers, alternate.